Thorsten Naab Title: Galaxy simulations with resolved ISM: clustered star formation, globular cluster formation and IMBH growth Abstract: We present recent highlights from the high-resolution simulation project GRIFFIN which allows to model the galactic turbulent multi-phase properties of the star forming interstellar medium (ISM). The models include non-equilibrium heating and cooling processes for the cool/cold ISM, the realization of individual stars in star forming regions, and the wind, ionization and supernova feedback from massive stars. We show with simulations of low metallicity galaxies, that the model reproduces realistic cold cloud and star cluster properties and that the clustering properties of massive stars have a strong impact on the formation of galactic outflows. In starburst environments, the model provides a self-consistent picture for the rapid hierarchical formation of globular clusters. In galactic centers with intermediate mass black holes (IMBHs) we highlight the difficulties to accurately follow accretion due to the competition between star formation and feedback from an accreting IMBH. We discuss limitations of the current models and promising ways forward towards a comprehensive understanding of the connection between ISM structure, clustered star formation, massive black hole growth and the launching mechanisms of galactic outflows.